CareLit Fachartikel
Genetic characteristics of the human hepatic stellate cell line LX–2
R Weiskirchen, J Weimer, N Arnold, L Xu, SL Friedman, C Bergmann · Zeitschrift für Gastroenterologie · 2012 · Heft 01
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820354
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2012
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Zusammenfassung
Based on their pivotal role in the initiation and progression of liver fibrogenesis, some major issues on fibrogenesis including the regulation of extracellular matrix (ECM) components, retinoid metabolism, and mechanisms of fibrogenic signalling are addressed in primary hepatic stellate cells (HSC) worldwide [1]. These cells execute a highly dynamic programme from quiescence to activation ending in a transdifferentiated phenotype termed myofibroblasts (MFB). Although the preparation of these primary cells is well established [2], the methodologies are time-consuming and most often require ethical and institutio…
Schlagworte
LX-2
cell models
fibrosis.
hepatic stellate cells
immortalized cells
karotyping
Biology
Zeitschrift für Gastroenterologie
