CareLit Fachartikel
Genistein shows beneficial effects on hepatic lipid metabolism in an in vitro hepatic steatosis model
A Krüger, S Lünse, G Damm, M Glanemann · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
820356
CareLit-ID
Jahr
2012
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Non-alcoholic fatty liver disease (NAFLD) is a pervasive disease leading to durable morphologic and biochemical changes, including steatosis, inflammation, fibrosis and cirrhosis. Epidemiologic studies suggest that Genistein (GEN) improves hepatic lipid levels. Our aim was to apply an in vitro steatosis model on primary human hepatocytes to investigate the effects of GEN on lipid metabolism. Primary human hepatocytes (PHH) were isolated from human liver resectates using a two step collagenase perfusion technique. PHH were treated with oleic acid and palmitate for 24h. GEN was then applied for 24h in concentratio…
Schlagworte
genistein
hepatic steatosis
lipid metablism
ppar alpha
srebp1c
Lipid
Steatosis
Hepatic
Content
Vitro
Model
Levels
Human
Pparalpha
Significantly
Effects
