CareLit Fachartikel
Melanocortin receptors in rat liver cells: change of gene expression and intracellular localization during acute-phase-response
IA Malik, J Triebel, J Posselt, P Ramadori, D Raddatz, G Ramadori · Zeitschrift für Gastroenterologie · 2012 · Heft 01
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820360
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Jahr
2012
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Zusammenfassung
Melanocortin receptors (MCRs) are known to be expressed predominantly in the brain where they exert metabolic and anti-inflammatory functions. Furthermore, the brain MCRs are supposed to also mediate anti-inflammatory effects in other organs. As serum levels of MCRs-ligands are elevated in clinical situation (acute-phase-response (APR)) of tissue damage, we studied hepatic gene expression of MCRs in a model of muscle tissue damage induced by turpentine-oil (TO) injection in rats. A significant increase in gene expression of all five MCRs (MC4R was the highest) in liver at the RNA and protein level was detected a…
Schlagworte
cytokines
liver
melanocortin
Chemokines
After
Zeitschrift für Gastroenterologie
