Persistent HCV-infection and liver damage change vitamin-D-metabolism
A Amanzada, A Lindhorst, F Moriconi, M Blaschke, T Suermann, S Mihm, G Ramadori · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction: Low vitamin D (vit. D) serum concentrations have been found in patients with chronic hepatitis C. A genetic background has been supposed. Methods: We analyzed pre- and post-treatment 25-OH vit. D levels in 126 genotype 1 chronic HCV-infected patients. Genetic polymorphisms of CYP27B1 rs10877012 within the vit.-D-cascade and of IL28B rs12979860 were determined. Conventional prognostic features were also assessed. Results: Mean value of pretreatment serum 25-OH vit. D level was decreased in all patients but 36% had pretreatment vit. D levels above >20 ng/ml. Polymorphism of CYP27B1 was not associated…
