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IgG4-positive plasma cells can be elevated in malignant hepato-biliary and pancreatic diseases and do not allow discrimination between neoplastic and autoimmune disease

Y Resheq, A Quaas, D von Renteln, D von Renteln, C Schramm, AW Lohse, S Lüth · Zeitschrift für Gastroenterologie · 2012 · Heft 01

Dokument
820367
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
Y Resheq, A Quaas, D von Renteln, D von Renteln, C Schramm, AW Lohse, S Lüth
Ausgabe
Heft 01 / 2012
Seiten
–
Erschienen: 2012-01-09 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0031-1295930

Zusammenfassung

Aims: Diagnosis of IgG4 associated cholangitis (IAC) and autoimmune pancreatitis (AIP) is challenging since both autoimmune diseases frequently mimic the clinical and radiological profile of hilar cholangiocarcinoma and pancreatic adenocarcinoma, respectively. High levels of IgG4-positive plasma cells on histology have been described as specific diagnostic parameter of IAC and AIP. This study aims to evaluate this specificity by analysing the frequency of IgG4-positive plasma cells in malignant diseases of the pancreatico-biliary tract. Methods: Sixty-one patients with malignant tumours of the hepatobiliary trac…

Schlagworte

Cholangiocarcinoma Adenocarcinoma Autoimmune Diseases Cholangitis Cholestasis Bilirubin Diagnosis Alanin Alanin-Aminotransferase Zeitschrift für Gastroenterologie