TGR5 (Gpbar–1) is expressed in cholangiocarcinomas and confers apopotosis resistance in isolated cholangiocytes
V Keitel, R Reinehr, M Reich, A Sommerfeld, K Cupisti, WT Knoefel, D Häussinger · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Cholangiocarcinomas (CCA) are malignancies of the biliary tract with limited treatment options. The molecular mechanisms leading to the development of CCA are unknown, however, chronic inflammation and elevated bile acid levels have been implicated in the pathogenesis of CCA. TGR5 is a membrane-bound bile acid receptor, which is expressed in cholangiocytes. Aim of the present study was to analyze the expression of TGR5 in CCA and to determine the role of TGR5 for cholangiocyte proliferation and apoptosis. Results: Liver tissue was collected from 18 patients undergoing liver resection for CCA (3 PSC patients). If…
