Loss of SIRT6 in hepatocellular carcinomas: associated molecular traits and clinical implications
JU Marquardt, K Fischer, A Teufel, M Krupp, SS Thorgeirsson, PR Galle, S Strand · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Bibliografische Angaben
Zusammenfassung
Sirtuin 6 (SIRT6) is a member of the sirtuin family of NAD-dependent deacetylases. It is involved in epigenetic regulation of many cellular processes such as DNA repair, fat metabolism, glucose homeostasis and aging by interacting with key molecules and signaling pathways such as NF-kB and HIF1A. Loss of SIRT6 results in uncontrolled glycolysis, triglyceride synthesis, and increased oxidative stress ultimately leading to hepatic steatosis. The role of SIRT6 in hepatocarcinogenesis remains to be elucidated.SIRT6 expression was investigated in primary human liver cancers, normal and cirrhotic livers using gene exp…
