CareLit Fachartikel
Porenbildende Toxine und mucosale Integrität
Roland Bücker, Michael Fromm, Jörg-Dieter Schulzke · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
820523
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben
Zusammenfassung
Abstract This short communication focuses on the role of hemolysins from barrier-breaking bacteria in mucosal damaging. Pore-forming toxins (PFTs), produced by hemolytic bacteria, are secreted proteins that integrate into the membrane of host cells and form pores, which are frequently cytolytic. But beyond these cytolytic effects, PFTs can induce a variety of defined pathogenic processes. Depending on the toxin, intestinal epithelial function can be impaired by e.g. secretion, induction of lesions or tight junction disturbance. The latter was shown as leak flux mechanism in diarrhea, by which water and small sol…
Schlagworte
Chloride
Bacteria
Claudins
Diarrhea
After
Clostridium perfringens
Aeromonas hydrophila
Chloride Channels
Intestinal Mucosa
Clostridium
Aeromonas
Apoptosis
Bakterien
Claudin-3
Calcium
Bacterial Translocation
