NAMPT-dependent deacetylation of the hematopoietic-specific lyn-substrate 1 (HCLS1)

Recently, we demonstrated an essential role of the hematopoietic cell-specific Lyn substrate 1 (HCLS1 or HS1) protein in myeloid differentiation of human and mouse hematopoietic cells. HCLS1 is an interaction partner of HAX1, which is mutated in patients with severe congenital neutropenia (CN). In these patients HCLS1 expression and functions are severely downregulated, leading to “maturation arrest” of myelopoiesis. We also described the new pathway of myeloid differentiation downstream of G-CSF in healthy individuals and in CN patients: G-CSF induced Nampt and NAD+, which activated NAD+-dependent protein deace…