Correlation of abdominal pain with fecal cystein-protease activity in irritable bowel syndrome patients with constipation (IBS-C)
R Róka, A Annaházi, V Bézirard, L Ferrier, H Eutamene, O Inczefi, K Gecse, A Rosztóczy, T Molnár, Y Ringel, T Ringel-Kulka, T Piche, V Theodorou, T Wittmann, L Bueno · Zeitschrift für Gastroenterologie · 2012 · Heft 05
Bibliografische Angaben
Zusammenfassung
Introduction: Previously we have shown that fecal cystein-protease activity is significantly elevated in IBS-C patients compared to control subjects. In animal experiments, colorectal infusion of fecal supernatants from IBS-C patients increase gut paracellular permeability and provokes a visceral hypersensitivity to distension. This increase is linked to the enzymatic digestion of the tight junction proteins by the cystein-proteases contained in these fecal supernatants. Aims: Our aims were to explore if there is a correlation between fecal cystein-protease activity and symptoms in IBS-C patients. Materials and…
