Effect of the herbal preparation, STW 5, in a stress-induced model of functional dyspepsia
MT Khayyal, H Abdel-Aziz, W Wadie, HF Zaki, O Kelber, D Weiser · Zeitschrift für Phytotherapie · 2012 · Heft 05
Bibliografische Angaben
Zusammenfassung
Psychological factors, especially stress, are known to play an important role in functional gastrointestinal diseases (1, 2). Based on the good correlation between stress and functional dyspepsia (FD), many animal models for FD have been developed where animals are subjected to psychological stress either during the neonatal period or in adulthood. This stress was found to induce gastric motor dysfunction resembling symptoms of FD. In one model, maternal separation (3) was performed on weanling rats starting from postnatal day 2 for 3h each day for 3 weeks. Rats were then allowed to mature to an adult age. The o…