Genetic factors associated with histologic features of the liver and treatment outcome in chronic hepatitis C patients
AF Stättermayer, K Rutter, S Beinhardt, TM Scherzer, H Hofer, P Steindl-Munda, M Trauner, P Ferenci · Zeitschrift für Gastroenterologie · 2012 · Heft 05
Bibliografische Angaben
Zusammenfassung
Aims: In chronic hepatitis C, steatosis is associated with fibrosis and impaired response to antiviral therapy. Recently several SNPs were identified in patients with NAFL/NASH which may causally link to hepatic fat accumulation and progression to fibrosis. Among them SNP rs738409 in the adiponutrin gene (PNPLA3) received most attention. A polymorphism of farnesyl diphosphate farnesyl transferase 1 (FDFT1) in rs2645424 was reported to be associated with NASH (Chalasani N., Gastroenterology 2010). Our aim was to evaluate the impact of these SNPs on steatosis, fibrosis and treatment outcome in patients with chroni…
