Insulin up-regulates natriuretic peptide clearance receptor expression in the subcutaneous fat depot in obese subjects: a missing link between CVD risk and central obesity?
O Pivovarova, Ö Gögebakan, N Klöting, A Ernst, MO Weickert, I Haddad, VJ Nikiforova, A Bergmann, M Kruse, AC Seltmann, M Blüher, AFH Pfeiffer, N Rudovich · Diabetologie und Stoffwechsel · 2012 · Heft 05
Bibliografische Angaben
Zusammenfassung
Aims: Natriuretic peptides (NPs) regulate cardiovascular homeostasis and have multiple metabolic properties. Decreased levels of NP or “natriuretic handicap” are signs of insulin resistance such as central obesity. Increased expression of natriuretic peptide clearance receptor (NPRC) in subcutaneous adipose tissue (SAT) was observed in insulin resistant subjects. We hypothesized that insulin acutely regulates NPR receptors expression in adipose tissue. Methods: NPRA, NPRB and NPRC mRNA expression was measured in paired samples of visceral (VAT) and SAT from 157 subjects with (n=108 with type 2 diabetes). Regulat…
