Role of Interleukin-1 (IL-1)-receptor-associated kinase 1 (IRAK-1) in pulmonary inflammation

Background: A crucial transducer of many Toll-like receptor (TLR) and IL-1 signalling pathways is IRAK-1. IRAK-1 deficient macrophages and fibroblasts show impaired responses to TLR ligands like lipopolysaccharide (LPS). However, the role of IRAK-1 in pulmonary inflammation has not been investigated yet. Methods: IRAK-1 knockout (KO) and WT mice were challenged for 9h or 24h intranasally with either high or low doses of LPS. Lung inflammation and cytokine secretion were analyzed afterwards. Results: Intranasal challenge of IRAK-1 deficient mice with a low dose of LPS showed a diminished pulmonary TLR4 response c…