CareLit Fachartikel
DNA demethylation of the IFNγ locus attenuates experimentally induced asthma
D Kesper, S Brand, RO Pinkenburg, H Garn, PI Pfefferle, H Renz · Pneumologie · 2012 · Heft 05
Dokument
821026
CareLit-ID
Jahr
2012
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Background: Polarization of T cells towards a Th2 cell based immune reaction is one of the key events in the development of allergic asthma. During the polarization process the Th-1 cytokine IFNγ is silenced by epigenetic mechanisms like de novo DNA methylation while Th2 cytokines are up regulated. Method: In order to show that epigenetic regulation by DNA methylation is essential for Th1 versus Th2 cell polarization and for the development of an asthmatic phenotype, the DNA methylation at the IFNγ- and the Th2 cytokine locus after the induction of experimental asthma was measured. Mice were treated with the DNA…
Schlagworte
Asthma
Cytokine
After
Deoxycytidine
Cytokines
Demethylation
Pneumologie
