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Identification of alveolar fibroblast subset-specific miRNA expression profiles and their impact on cell development, differentiation and subsequently alveolar septation in postna…

DA Szerlowska, K Ahlbrecht, J Willhelm, H Hackstein, W Seeger, R Voswinckel · Pneumologie · 2012 · Heft 05

Dokument
821028
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Jahr
2012
Publikation
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
DA Szerlowska, K Ahlbrecht, J Willhelm, H Hackstein, W Seeger, R Voswinckel
Ausgabe
Heft 05 / 2012
Seiten
–
Erschienen: 2012-05-31 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0032-1315500

Zusammenfassung

Introduction: It is known that the microRNAs (miRNAs) are involved in basic cell processes, coregulated by many other factors (cytokins, cell receptors, transcription factors), which all together form a sophisticated signaling networks important in maintaining tissue homeostasis and development. We aim to identify cell specific miRNA expression profiles of different lung fibroblast subpopulations, such as myofibroblast, lipofibroblast and PDGFRa- precursor cells, which are critically involved during mouse alveolar septum formation. Methods: Based on specific gene expression of postnatal lung interstitial fibrobl…

Schlagworte

Fibroblast Mirna Expression Cells Processes Specific Might Profiles Differentiation Postnatal Alveolar Development Pneumologie