Remodelling-related molecular profiles in interstitial pulmonary fibrosis
D Jonigk, J Rische, L Maegel, H Golpon, N Izykowski, CL Bockmeyer, T Welte, S Janciauskiene, J Gottlieb, G Warnecke, A Haverich, H Kreipe, F Laenger · Pneumologie · 2012 · Heft 05
Bibliografische Angaben
Zusammenfassung
Rationale: Idiopathic pulmonary fibrosis (IPF) is the most representative of the idiopathic interstitial pneumonia group (IIP) and is a disease characterized by an overall poor prognosis and unresponsiveness to currently available therapies. Thus elucidation of molecular pathways to gain better insight into the pathogenesis and identify potential therapeutic targets is warranted. Methods: We performed compartment-specific analyses using laser microdissection, RT-PCR based microarray techniques and immunohistochemistry in lung samples from well defined patients with UIP, nonspecific interstitial pneumonia (NSIP),…
