Function of NADPH oxidase 1 in pulmonary arterial smooth muscle cells from monocrotaline-induced pulmonary hypertension
F Veit, B Egemnazarov, M Roth, D Kosanovic, O Pak, HA Ghofrani, W Seeger, F Grimminger, RT Schermuly, N Weissmann · Pneumologie · 2012 · Heft 05
Bibliografische Angaben
Zusammenfassung
Chronic alveolar hypoxia induces pulmonary hypertension (PH) and pulmonary vascular remodeling. Reactive oxygen species (ROS) are thought to play a major role in this process. Recent findings suggested that ROS production by NADPH oxidase 4 (Nox4) is plays an important role for PH development in hypoxia-induced PH in mice and human idiopathic pulmonary arterial hypertension (IPAH). Against this background we investigated whether NADPH oxidases are also active in PH development induced by monocrotaline (MCT) in rats. ROS production, their possible sources and their impact on the function of pulmonary arterial smo…
