PAR-2 expression by BALF epithelial cells and BALF cytokine profiles in patients with different interstitial lung diseases

Background: Idiopathic pulmonary fibrosis (IPF), hypersensitivity pneumonitis (HP) and sarcoidosis belong to interstitial lung diseases (ILDs). Changes in lung cytokine environment were observed in different ILDs. An important role in pathogenesis of fibroproduction may also play proteinase activated receptor –2 (PAR-2). The aim of this study was to compare cytokines and PAR-2 expression by various cells in bronchoalveolar lavage fluid (BALF) among different types of ILDs and control group. Objective: To compare TNFalpha, INFgamma, IL-2 and PAR-2 expression by cells in BALF in patient groups Design: 31 patients…