Influence of ANXA11 genotype on sensitivity of peripheral blood mononuclear cells to apoptosis in sarcoidosis and its phenotypes

Sarcoidosis is a granulomatous disorder of an unknown etiology, where the granuloma formation has been associated with impaired apoptosis of activated inflammatory cells. There is no information concerning the influence of ANXA11 R230C, a functional annexin A11 variant associated with protection/disease modification of sarcoidosis, on the sensitivity of peripheral blood mononuclear cells (PBMC) to apoptosis yet. We therefore compared the sensitivity to apoptosis of PBMC obtained from 92 sarcoid patients and 14 healthy controls. Tributyltin was used as apoptosis stimulus; annexin V positive cells were detected by…