Treatment of newborns with severe injured brain with transplantation of human neural precursor cells

Objective: Evaluate the feasibility of human neural precursor cells transplantation for treatment of neonates with severe brain injury. Methods: The transplantation was performed on 6 newborns, five male patients and one female patient (ages 2–10 days). One was diagnosed as extremely severe carbon monoxide poisoning at 5th day after birth; one was diagnosed as severe hypoglycemia; the others were diagnosed as severe neonatal asphyxia, severe hypoxic ischemic encephalopathy. Under the agreement of hospital ethical committee and informed consent of the family members, the newborns received human neural precursor c…