Nrf2 regulates antioxidative and liver regeneration promoting genes

The liver is frequently challenged by insults such as toxins and alcohol, viral infection or metabolic overload. In contrast to other organs, the liver has a unique capability to regenerate after injury. However, sustained presence of the damaging insult prolongs the regeneration response, resulting in liver fibrosis and cirrhosis or acute liver failure. Liver regeneration can be impaired by permanent oxidative stress mediated by the formation of reactive oxygen species (ROS). ROS are produced by metabolic intermediates of xenobiotics, mitochondrial leakage, induction of CYP2 family and activation of inflammator…