Second Line Therapy in Autoimmune Hepatitis: is Mycophenolate Mofetil an effective option?

Autoimmune hepatitis (AIH) has a good prognosis when the inflammatory reaction is sufficiently suppressed and the development of cirrhosis is prevented. Steroids and Azathioprin (AZA) are established for first-line-therapy. However, there is no established regimen in case of ineffectiveness of this combination. Results from a small study suggest Mycophenolate Mofetil (MMF) to be effective in patients with AZA intolerance. However, these data also showed MMF ineffectiveness in the majority of patients with prior non-response to AZA. Therefore, the aim of this study was to further evaluate second-line regime with…