Hepatocellular carcinoma does not significantly contribute to the risk of hepatobiliary malignancy in cirrhotic patients with primary sclerosing cholangitis

Background and aims: Primary sclerosing cholangitis (PSC) is associated with an increased risk of hepatobiliary and gastrointestinal malignancy. There are few studies evaluating the risk of hepatocellular carcinoma (HCC) in PSC cirrhosis and a frequency of HCC in PSC patients undergoing orthotopic liver transplantation of 2% has been suggested. The aim of this study was to determine the risk of HCC in PSC cirrhosis and to compare it to the risk of cholangiocarcinoma (CCA) and gall bladder cancer (GBC) as well as colorectal cancer (CRC). Methods: We included 509 patients with well defined PSC into this retrospect…