Dissecting the role of the immune system in liver injury and hepatocarcinogenesis”
J Endig, J Lamlé, LE Buitrago-Molina, S Marhenke, T Longerich, R Geffers, F Limbourg, H Strick-Marchand, MP Manns, A Vogel · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: Activation of the immune system by tumor cells might result in eradication of malignant cells. In this regard, modulation of the immune system has been shown to increase carcinogenesis in several knock-out models. However, there is increasing evidence that chronic activation of the immune system in pre-malignant tissues might also promote tumor development. In order to characterize the role of the immune system in chronic liver injury and hepatocarcinogenesis mouse model of hereditary tyrosinemia type 1 (HT1) was used. HT1 is a genetic defect of tyrosine catabolism and is characterized by an extremel…
