Hepatobiliary malignancies in Wilson disease

Introduction: Wilson disease (WD) is a rare inherited copper overload disorder leading to chronic liver failure. While hepatobiliary malignancies are common in patients with chronic end stage liver diseases, reports on liver tumors in Wilson disease patients are scarce. The present study aims to determine the frequency and type of hepatobiliary malignancies in WD patients. Patients and Results: Data of 512 WD patients were analyzed retrospectively. Cases with liver malignancies were identified and characterized. Six patients in our cohort developed hepatobiliary malignancies over time (median follow up 16.7 year…