Virotherapeutic treatment of HCC by novel genetically modified Sendai viruses exhibiting strong oncolytic efficiencies

Introduction: Virotherapy provides an alternative new mechanistic treatment approach for hepatobiliary tumors and others, based on a selective viral replication in tumor cells, inducing cellular destruction. To reach a broad range of different tumors and select an ideal vector system for each disease entity, including especially tumors of hepatobiliary origin, it is challenging to develop new oncolytic viruses with attractive properties. Murine parainfluenza virus type I (Sendai virus, SeV) is a murine pathogen that infects human cell types in a highly efficient manner. SeV has entered clinical trials recently;…