Anti-neutrophil cytoplasmic antibodies in bile are associated with disease activity in primary sclerosing cholangitis
H Lenzen, TJ Weismüller, AA Negm, J Wlecke, CP Strassburg, MP Manns, TO Lankisch · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background and Aims: Primary sclerosing cholangitis (PSC) is an autoimmune cholestatic liver disease of unknown aetiology. The role of anti-neutrophil cytoplasmic antibodies (ANCA) in the serum of patients with PSC remains unclear. Because inflammation of PSC takes place in the biliary epithelium, we hypothesised that ANCA may be detectable in bile, potentially providing diagnostic and prognostic information. Methods: Bile and serum were prospectively collected during endoscopic retrograde cholangiography (ERC) in 68 patients. ANCA, antinuclear antibody (ANA) and anti-saccharomyces cerevisiae antibody (ASCA) mea…
