Comparative functional genomics of autoimmune hepatitis; mechanistic and clinical implications
JU Marquardt, D Becker, JB Andersen, D Seidel, I Eickmeier, PS Ploch, T Gamstätter, T Hansen, L Conner, PR Galle, E Schott, SS Thorgeirsson, A Teufel · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Autoimmune hepatitis (AIH) is a major chronic liver disease characterized by diverse and pleiotropic spectrum of different phenotypes. Despite recent progress in clinical management of AIH patients, the exact molecular pathogenesis remains largely unknown. Here, we used a comparative genomic approach to define molecular characteristics and test the predictive value of gene expression profiles in this important liver disease. Gene expression profiles of 124 patients with different chronic liver diseases (AIH, HBV, HCV) were generated from FFPE samples using Illumina DASL assay and computationally integrated with…
