IFNs and ISGs are up-regulated in HBV-transgenic mice lacking HBsAg
CI Real, R Broering, M Trippler, K Jahn-Hofmann, L Ickenstein, M John, K Kleinehr, S Driftmann, T Kemper, HP Vornlocher, J Reimann, R Schirmbeck, M Lu, G Gerken, JF Schlaak · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction: Chronic infection with the hepatitis B virus (HBV) is a major cause of liver-related morbidity and mortality world-wide. Previously, it has been suggested that chronicity of infection may be facilitated by an attenuation of innate and adaptive immune responses through HBsAg. Here, we have studied the immunological effects of a transgenic construct encoding for HBV but lacking HBsAg in a mouse model. We have also studied the effects of an efficient, hepatocyte-specific, siRNA-based system to suppress HBV replication in this system in vivo. Methods: Different nanolipid-formulated siRNAs specific to t…
