Labdane-type diterpenes and other lipophilic constituents from cardioactive Leonurus cardiaca L.: Analytical and preparative chromatography as well as structural determination

Continuing our search for possible cardioactive single constituents of primary and refined antiarrhythmic extracts of Leonurus cardiaca L. [1] we focused on the group of furanic labdane type diterpenes and other lipophilic compounds. The paper attended reports herewith the isolation of five diterpenes besides known lipophilic substances, like sitosterol, stigmasterol, genkwanin and ursolic acid. In accordance to Knöss et al. [2, 3] the postulated presence of leocardine [4] as a major reference substance of Leonurus cardiaca L. could not be confirmed. The structures of leopersine E, isoleosibirine, leopersine F a…