Role of circadian clock gene expression in metabolic adaptation upon switching from high to low carb diets with replacement by fat
O Pivovarova, S Hornemann, M Kruse, Y Lu, S Möckel, V Murahovschi, AC Seltmann, J Mazuch, N Rudovich, A Kramer, A Busjahn, AFH Pfeiffer · Diabetologie und Stoffwechsel · 2013 · Heft 04
Bibliografische Angaben
Zusammenfassung
Background and aims: The circadian clock coordinates numerous behavioural and physiological processes including feeding, energy metabolism and inflammatory responses. In turn, metabolic processes feed back onto the circadian clock. However, there is little information about the effect of nutrition on circadian mechanisms in humans. To address this, we analysed daily expression profiles of clock genes, LPS response and fat metabolism genes in human blood monocytes after 6 weeks high carbohydrate – low fat (HC/LFD, 55% carbohydrate, 30% fat) followed by 6 weeks of low carbohydrate – high fat (LC/HFD, 40% carbohydr…
