Increased cardiac oxidative stress in a mouse transgenic model of non-alcoholic fatty liver disease and insulin resistance

Introduction: Diabetic cardiomyopathy is characterized by impaired myocardial function and ischemic tolerance in patients with type 2 diabetes. This has been related to reduced oxidative capacity and increased oxidative stress in cardiomyocytes. Non-alcoholic fatty liver (NAFL) and insulin resistance are associated with increased cardiovascular risk and cardiac mortality. Here, we aimed to investigate how NAFL and insulin resistance relate to cardiac oxidative stress and mitochondrial oxidative capacity in mice. Methods: Female mice, aged 18 and 36 weeks (w), with adipose tissue-specific overexpression of the st…