Correlations of cholecalciferol-levels, daily insulin dose and clinical features in patients with Type 1 diabetes mellitus

Aims: Type 1 Diabetes mellitus(T1D) is caused by a complex process of altered humoral and cellular immunity, resulting in the destruction of insulin-producing cells. VD(25(OH)D3) insufficiency is implied as risk factor for T1D, whereas VD substitution in infantry is associated with a reduced risk of T1D. In T1D a daily insulin injection is required for a stable glucose homeostasis and insulin demand rises by a higher Body Mass Index(BMI). Today there are no studies investigating the relationship between endogenous VD production and insulin demand in T1D. Patients and methods: Patients with T1D(n = 29) were exami…