Optical and MR-Imaging of inflammation via mononuclear phagocyte labelling with bimodal nanoparticles
J Domey, C Bergemann, I Krumbein, JR Reichenbach, S Bremer-Streck, WA Kaiser, I Hilger · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2013 · Heft 04
Bibliografische Angaben
Zusammenfassung
Ziele: Inflammations have been described to be a reason for tumour genesis. Therefore the successful detection of inflammation with contrast media is important for aspects of therapeutics. Complex target-specific contrast-enhancing nanoparticles (NP) are well studied and bind specifically to cells but can also lead to cross-reactions. Here, we describe non-targeted bimodal optical and MRI NP with a fluorophore which is shielded by a starch-matrix from interactions with NP environment for imaging cells of the mononuclear phagocytic system (MPS). Methode: To produce bimodal nsIR780-NP magnetite cores were enclosed…
