Long-term outcome of perianal and enterocutaneus fistulizing Crohn's disease treated with Tumor Necrosis Factor Alpha (TNF-α) antagonists

Introduction: There are only limited clinical observational data about the short and long-term efficacy of anti tumor necrosis factor alpha (anti-TNF-α) therapy in patients with perianal and enterocutaneus fistulizing Crohn's disease (CD). Aims: The aim of this study was to retrospectively evaluate the outcomes, complications and therapeutic success ratein fistulizing CD patients. Patients and methods: The medical record of 69 patients (35 females, 33 males, mean age at the diagnosis is 26 years [range 10 – 62]) treated with anti-TNF-α (infliximab and adalimumab) between 2004 and 2012 for 61 perianal and 7 enter…