Successful Peginterferon-Alfa (PEG-IFN-α) treatment of a chronic hepatitis B (CHB) patient complicated with periarteritis nodosa. A case report

Introduction: Extrahepatic manifestations of HBV infection are rare, but can be difficult to diagnose and manage. HBV can sometimes cause skin rash, arthritis, glomerulonephritis, polyarteritis nodosa (PAN), glomerulonephritis, polyneuropathy and papular acrodermatitis. Case report: A 61-year-old male smoker was admitted to rheumatology unit with multiple arterial stenoses and a severe Raynaud phenomenon with necroses of the fingers on both hands and polyarthritis, predominantly in the lower limbs. The levels of transaminases were elevated, with an ALAT predominance. Anti-HCV and numerous autoimmune tests and rh…