Analysing the effect of imidazoline receptor agonists and antagonists on the gastric motility in mice

Introduction: Both imidazoline receptors and endogenous imidazoline ligands have been identified throughout the gastrointestinal (GI) tract, but their physiological role remains uncertain. On the other hand, functional GI disorders accompanied by motility disturbances (e.g. functional dyspepsia and idiopathic gastroparesis) are common clinical problems and new targets for drug development are needed. The present study was undertaken to clarify, whether the endogeous imidazoline system takes part in the modulation of gastric motility. Methods: Various imidazoline ligands were tested on the electrical field stimul…