Immunohistochemical analysis of protease activated receptor-2 (PAR2) and cyclooxygenase-2 (COX2) co expression in Barrett esophagus

Our previous results suggested that the metaplastic process resulting in Barrett's esophagus is considered as a regenerative answer to mixed duodenogastric reflux. We also established that PAR2 is expressed on the metaplastic cells, and the expression showed correlation with the histological stage of the disease. Furthermore we demonstrated that COX2 similarly correlated with the reflux severity. The aim of this study was to investigate the co expression of PAR2 and COX2 proteins in histological samples of patients with Barrett esophagus. Materials and methods: Sixty-four consequtive human esophageal biopsy samp…