Propofol mono vs. Propofol + Midazolam – a prospective evaluation of safety and subjective well-being in 24.441 patients

Aims of the study: In this prospective multicenter trial of 24.441 patients we evaluated the occurrence of adverse events and patients subjective condition regarding the sedation regimen of Propofol mono (P) or a combination of Propofol and Midazolam (P+M). Methods: In this prospective multicenter trial, 24.441 patients received endoscopic sedation with either P or P+M. 15.690 patients stated their subjective condition in a questionnaire 24 hours after the endoscopic procedure. Results: We observed 4 major adverse events (3 mask ventilations and 1 laryngospasm) in this study that occurred during 2 P and 2 P+M se…