A unifying concept for periampullary cancer

Introduction: Periampullary adenocarcinomas comprise pancreatic ductal (PDAC), distal bile duct (DBDAC), ampullary (AMPAC) and duodenal (DUOAC) adenocarcinoma. The epithelia of these anatomical structures share a common embryologic origin from the foregut. With steadily increasing numbers of pancreatoduodenectomies over the last decades, pathologists, surgeons and oncologists are more often confronted with the diagnosis of “other than pancreatic” periampullary cancers. The intestinal subtype of AMPAC has been shown to correlate with better prognosis. Methods: From = 198 cases of periampullary carcinoma with clin…