Beneficial effects of liraglutide on carotid intima-media thickness in patients with type 2 diabetes: a 8-month prospective study

Purpose: There is currently hightened interest in the extra-glycemic effects of incretin-based therapies. Specifically, the actions of glucagon-like peptide 1 (GLP-1) analogues on cardiovascular risk markers has garnered attention. Although liraglutide has been shown to have pleiotropic benefits, its effect on carotid intima-media thickness (CIMT), a recognized marker of subclinical atherosclerosis, is still largely unknown. Material and methods: We evaluated the effect of liraglutide on CIMT, as assessed by B-mode real-time ultrasound, in a prospective study of 64 patients with type 2 diabetes (32 men and 32 wo…