In utero exposure to mainstream cigarette smoke alters neonatal pulmonary signaling networks and postnatal lung function
S Dehmel, P Nathan, K Milger, R Prungnaud, R Imker, G John, A Önder Yildirim, M Irmler, J Beckers, O Eickelberg, S Krauss-Etschmann · Pneumologie · 2013 · Heft 12
Bibliografische Angaben
Zusammenfassung
Background & Aim: Epidemiologic studies showed that maternal smoking during pregnancy is a main risk factor to develop asthma later in life. However, the underlying mechanisms are insufficiently understood. MicroRNAs (miRs) act as master regulators of bronchoalveolar tissue morphogenesis and immune system development during embryo-fetal life. We therefore asked how maternal smoking during pregnancy affects 1) pulmonary maternal immune responses and 2) miR/mRNA networks in lungs of offspring in late fetal stage. Methods: Pregnant (P) and non-pregnant (NP) BALB/c mice were exposed to filtered air (FA) or mainstrea…
