Expression and function of methylthioadenosine phosphorylase (MTAP) in activated hepatic stellate
B Czech, D Valletta, K Dettmer, M Müller, A Bosserhoff, P Oefner, C Hellerbrand · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Bibliografische Angaben
Zusammenfassung
Regain methionine is essential for cellular metabolism and methylthioadenosine phosphorylase (MTAP), the rate-limiting enzyme in the methionine and adenine salvage pathway, catalyzes the phosphorylation of 5'-deoxy-5'-(methylthio)adenosine (MTA), which is a by-product of polyamine synthesis. The polyamine metabolic pathway has been implicated in the pathogenesis of chronic liver disease, and previous studies have shown that pharmacological doses of MTA (500µM and higher) exhibited anti-fibrotic effects in murine models of hepatic injury. The aim of this study was to assess MTAP expression as well as MTA levels i…
