Protective role of Ursodeoxycholyl Lysophosphatidylethanolamide during hepatic ischemia and reperfusion injury in mice

Introduction: Ischemia and reperfusion (I/R) injury of the liver which may occur during liver transplantation can cause severe complications leading to transplantation failure. We have designed cytoprotective agent ursodeoxycholyl lysophosphatidylethanolamide (UDCA-LPE), which has been shown to be protective in ameliorating apoptosis and inflammation in acute and chronic liver injury models, such as, endotoxic shock and feeding with high-fat diet. This study is aimed to explore whether UDCA-LPE can also serve as a protective agent against hepatic I/R injury in mice. Methods: Ischemia in C57/BL6 mice was introduc…