Higher frequency of peripheral CD3CXCR3 and CD4CXCR3 positive blood cells in HCV patients in context of bile acid retention
M Rau, J Schmitt, T Kudlich, JJG Marin, M Rodríguez Romero, H Klinker, HP Tony, B Müllhaupt, A Geier · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: Chronic hepatitis C infection is worldwide a leading cause of end stage liver disease. High levels of serum interferon-gamma-inducible protein-10 (IP-10) are associated to inferior antiviral therapy response. In a cohort of 300 HCV patients we recently showed an association between higher IP-10 serum levels, cholestasis and higher DPPIV serum activity. DPPIV was described as cleavage enzyme of serum IP-10 (Casrouge et al., JCI 2011) which induces an antagonist form of IP-10. Aims: To analyse PBMCs together with serum BA differentiation, DPPIV activity and IP-10 serum levels in patients with chronic h…
