Synthetic PreImplantation Factor (sPIF)# neuroprotective role in intracranial stem cell transplantation: Encephalopathy of prematurity rat model

Background: Premature birth is a major cause of neonatal morbidity and mortality. Although improvements in perinatal and neonatal care reduce mortality, morbidity remains a serious challenge. Survivors of premature birth will confront enormous neurological problems. Wharton's jelly-derived mesenchymal stem cells (WJ-MSC) are a promising source for cell transplant. Embryo-derived PIF modulates systemic maternal immunity without suppression. PIF also reverses neuroinflammation (severe paralysis) while imparting neuroprotective/neurogenerative activity (multiple sclerosis models) and prevents juvenile diabetes whil…