Generation of vascular progenitor cells from ES cells and iPS cells for medical applications

Objective and Aim: Establishing of induced pluripotency in the cells derived from mice and humans to generate endothelial cells for cell based therapies of vascular or parenchymal diseases of the lung. Endothelium is of crucial importance for the maintenance of vessel function, thus endothelial dysfunction is seen in a variety of pathological conditions. Human embryonic stem (hES) cells – derived differentiated cells hold broad treatment applications. Generation of these cells is ethically debatable. Development of pluripotent stem cells – from somatic cells – holds promise for regenerative medicine and biomedic…