A novel mouse model to decode the function of immunoglobulin E in allergy

Introduction: Human allergy is a debilitating disease in developed countries. Its symptoms range from hay fever attacks, dermatitis, asthma to life threatening anaphylaxis. While decades of research have shown that chronic inflammation driven by B cells and allergen specific immunoglobulin is at the core of the disease, we still lack an in depth understanding of regulatory mechanisms involved. In particular, we still lack good experimental models, which faithfully mimic human allergy. Methods: In this work the authors generated an IgE over-expressing mouse, by knocking-in IgE into the IgG1 gene locus. Results: T…