Bilateral enlargement of caudate nucleus in a child with polymicrogyria

Introduction: The caudate nucleus (CN) receives connections from all major ipsi- and contralateral cortical regions. The embryologic development of corticostriatal neurons and of striatal and cortical interneurons is still under investigation. In mice, an interaction between neuron migration to the cortex and striatum has been described in early development [1]. In cats, a CN enlargement has been reported following prenatal cortical lesioning [2]. In humans, corticostriatal connections are thought to be involved, apart from Parkinson and Huntington disease, in autism and psychiatric diseases [3]. A recent study…